Use in sport Codeine use in sport - not prohibited but use may be monitored.

Nonsteroidal Anti-inflammatory Drugs
Include: COX-2 selective: celecoxib, etoricoxib, parecoxib.
Nonselective: diclofenac, ibuprofen, indometacin, ketoprofen, ketorolac, mefenamic acid, meloxicam, naproxen, piroxicam, sulindac, diclofenac sodium + misoprostol.
Mode of action: NSAIDs suppress prostaglandin and thromboxane synthesis via inhibition of the enzyme cyclooxygenase (COX). Nonselective NSAIDs reversibly and competitively inhibit the two COX isoenzymes (COX-1 and COX-2). Inhibition of COX-2 accounts for the therapeutic anti-inflammatory, analgesic and antipyretic effects of NSAIDs, while inhibition of COX-1 is associated with GI toxicity. Selective COX-2 inhibitors retain the efficacy of NSAIDs in relieving inflammation and pain while reducing GI toxicity risk.
Use: RA, OA, inflammatory arthropathies (ankylosing spondylitis, psoriatic arthritis, Reiter's syndrome), acute gout, pain (metastatic bone, postoperative, dental, dysmenorrhoea), headache, migraine, fever, mild-chronic inflammatory and tissue injury pain. Indometacin is also available as an injection for PDA closure in premature infants (see Section 2n).
Special populations: Pregnancy: human data suggest risk in 1st and 3rd trimesters; assess potential benefit/risk; not recommended during labour and delivery.
Lactation: no or limited human data; excreted in breast milk in generally small amounts; sulindac and selective COX-2 inhibitors have toxicity potential; other NSAIDs are not recommended but probably compatible.
Children: ibuprofen is suitable for children ≥ 3 months; safety and efficacy of other NSAIDs is generally not established for children ≤ 12-18 years.
Cardiac, hepatic, renal impairment, elderly: risk of NSAID toxicity is increased in these populations.
Practice points: There is a serious risk of CV thrombotic events (including MI, stroke) and GI adverse events (including bleeding, ulceration, perforation) which can be fatal. High risk patient populations should use the lowest effective NSAID dose for the shortest possible duration.

PBS Brand Substitution
Interchangeable brands in this section.
Celecoxib: Celebrex ↔ APX-Celecoxib ↔ Blooms Celecoxib ↔ Blooms the Chemist Celecoxib ↔ Celaxib ↔ Celecoxib GH ↔ Celecoxib Sandoz ↔ Celecoxib-WGR ↔ Celexi.
Diclofenac: Voltaren ↔ Clonac ↔ Diclofenac Sandoz ↔ Diclofenac-WGR ↔ Fenac EC.
Ibuprofen: Brufen ↔ APO-Ibuprofen 400 ↔ WGR-Ibuprofen 400.
Indometacin: Indocid ↔ Arthrexin.
Mefenamic acid: Ponstan ↔ Femin.
Meloxicam: Mobic ↔ APO-Meloxicam ↔ APX-Meloxicam ↔ Cipla Meloxicam ↔ Melobic ↔ Meloxibell ↔ Meloxicam Sandoz ↔ Meloxicam Viatris ↔ Meloxicam-WGR ↔ Moxicam Capsules.
Naproxen sodium: Anaprox 550 ↔ Crysanal.
Naproxen SR: Naprosyn SR ↔ Proxen SR.